Overview

  • Product nameAnti-MyD88 antibody
    See all MyD88 primary antibodies
  • Description
    Rabbit polyclonal to MyD88
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:

    CDFQTKFALSLSPGAH

    , corresponding to C terminal amino acids 233-248 of Human MyD88.

  • Positive control
    • Human spleen cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab47185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 33 kDa).

Target

  • FunctionAdapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
  • Tissue specificityUbiquitous.
  • Involvement in diseaseDefects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
  • Sequence similaritiesContains 1 death domain.
    Contains 1 TIR domain.
  • DomainThe intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Mutant myeloid differentiation primary response 88 antibody
    • MYD 88 antibody
    • Myd88 antibody
    • MYD88_HUMAN antibody
    • MYD88D antibody
    • Myeloid differentiation marker 88 antibody
    • Myeloid differentiation primary response 88 antibody
    • Myeloid differentiation primary response gene (88) antibody
    • Myeloid differentiation primary response gene 88 antibody
    • Myeloid differentiation primary response gene antibody
    • Myeloid differentiation primary response protein MyD88 antibody
    • OTTHUMP00000161718 antibody
    • OTTHUMP00000208595 antibody
    • OTTHUMP00000209058 antibody
    • OTTHUMP00000209059 antibody
    • OTTHUMP00000209060 antibody
    see all

Anti-MyD88 antibody images

  • Anti-MyD88 antibody (ab47185) at 0.5 µg/ml + Human spleen cell lysate

    Predicted band size : 33 kDa
    Observed band size : 32 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 21 kDa. We are unsure as to the identity of these extra bands.

References for Anti-MyD88 antibody (ab47185)

ab47185 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"