Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-IKYKAM KKEFP
    • Amino acids
      255 to 265

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-MyD88 antibody (ab28763)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Mutant myeloid differentiation primary response 88
    • MYD 88
    • Myd88
    • MYD88_HUMAN
    • MYD88D
    • Myeloid differentiation marker 88
    • Myeloid differentiation primary response 88
    • Myeloid differentiation primary response gene
    • Myeloid differentiation primary response gene (88)
    • Myeloid differentiation primary response gene 88
    • Myeloid differentiation primary response protein MyD88
    • OTTHUMP00000161718
    • OTTHUMP00000208595
    • OTTHUMP00000209058
    • OTTHUMP00000209059
    • OTTHUMP00000209060
    see all
  • Function
    Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
  • Sequence similarities
    Contains 1 death domain.
    Contains 1 TIR domain.
  • Domain
    The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab45704 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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