Anti-Myelin Protein Zero antibody (ab77354)

Overview

  • Product nameAnti-Myelin Protein Zero antibody
    See all Myelin Protein Zero primary antibodies
  • Description
    Goat polyclonal to Myelin Protein Zero
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Horse, Cow, Dog, Human, Pig
  • Immunogen

    Synthetic peptide:

    DHSRSTKAVSEK

    , corresponding to internal sequence amino acids 224-235 of Human Myelin Protein Zero

  • Positive control
    • Rat Spinal Cord lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab77354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/32,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCreation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
    • Tissue specificityFound only in peripheral nervous system Schwann cells.
    • Involvement in diseaseDefects in MPZ are the cause of Charcot-Marie-Tooth disease type 1B (CMT1B) [MIM:118200]. CMT1B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
      Defects in MPZ are the cause of Charcot-Marie-Tooth disease type 2I (CMT2I) [MIM:607677]. CMT2I is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2I is characterized by late onset (range 47 to 60 years).
      Defects in MPZ are the cause of Charcot-Marie-Tooth disease type 2J (CMT2J) [MIM:607736]. CMT2J is a form of Charcot-Marie-Tooth disease characterized by the association of axonal peripheral neuropathy with hearing loss and pupillary abnormalities such as Adie pupil. Inheritance is autosomal dominant.
      Defects in MPZ are the cause of Adie pupil (ADIEP) [MIM:103100]. A stationary, benign disorder characterized by tonic, sluggishly reacting pupil and hypoactive or absent tendon reflexes. Adie pupil is a characteristic of Charcot-Marie-Tooth disease type 2J.
      Defects in MPZ may be the cause of Charcot-Marie-Tooth disease dominant intermediate type D (CMTDID) [MIM:607791]. CMTDID is a form of Charcot-Marie-Tooth disease characterized by features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
      Defects in MPZ are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
      Defects in MPZ are a cause of congenital hypomyelination neuropathy (CHN) [MIM:605253]. CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities.
      Defects in MPZ are a cause of Roussy-Levy syndrome (ROULS) [MIM:180800]; also known as Roussy-Levy hereditary areflexic dystasia. This autosomal dominant disorder resembles Charcot-Marie-Tooth disease type 1 in that it presents with foot deformity, weakness and atrophy of distal limb muscles, especially the peronei, and absent tendon reflexes. The phenotype differs, however, in that it includes static tremor of the upper limbs and gait ataxia.
    • Sequence similaritiesBelongs to the myelin P0 protein family.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications
      N-glycosylated; contains sulfate-substituted glycan.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Charcot Marie Tooth neuropathy 1B antibody
      • CHM antibody
      • CMT1 antibody
      • CMT1B antibody
      • CMT2I antibody
      • CMT2J antibody
      • CMT4E antibody
      • CMTDI3 antibody
      • CMTDID antibody
      • DSS antibody
      • HMSNIB antibody
      • MPP antibody
      • MPZ antibody
      • Myelin peripheral protein antibody
      • Myelin protein P0 antibody
      • Myelin protein zero antibody
      • MYP0_HUMAN antibody
      • P0 antibody
      see all

    Anti-Myelin Protein Zero antibody images

    • Anti-Myelin Protein Zero antibody (ab77354) at 0.1 µg/ml + Rat Spinal Cord lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 28 kDa
      Observed band size : 28 kDa

    References for Anti-Myelin Protein Zero antibody (ab77354)

    ab77354 has not yet been referenced specifically in any publications.

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