Overview

  • Product nameAnti-Myeloperoxidase antibody [1A1]
    See all Myeloperoxidase primary antibodies
  • Description
    Mouse monoclonal [1A1] to Myeloperoxidase
  • Tested applicationsSuitable for: IP, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein purified from Human sputum

  • Positive control
    • HL-60 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab51065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent dilution. Use 2µg for 400µl lysate.
ELISA Use at an assay dependent dilution.

Target

  • FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
  • Involvement in diseaseDefects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
  • Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 84 kDa myeloperoxidase antibody
    • 89 kDa myeloperoxidase antibody
    • EC 1.11.1.7 antibody
    • EC1.11.2.2 antibody
    • fj80f04 antibody
    • MPO antibody
    • mpx antibody
    • myeloid-specific peroxidase antibody
    • Myeloperoxidase antibody
    • Myeloperoxidase heavy chain antibody
    • Myeloperoxidase light chain antibody
    • PERM_HUMAN antibody
    • wu:fj80f04 antibody
    see all

Anti-Myeloperoxidase antibody [1A1] images

  • Immunoprecipitation analysis of HL-60 cell lysate with ab51065 at 2µg for 400µl of lysate. Lane 1: Input; Lane 2: Precipitates. Western blot detection was done with ab76100.

References for Anti-Myeloperoxidase antibody [1A1] (ab51065)

This product has been referenced in:
  • Silvescu CI & Sackstein R G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A 111:10696-701 (2014). IP ; Human . Read more (PubMed: 25002508) »
  • Huang Y  et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest 123:3815-28 (2013). IP ; Human . Read more (PubMed: 23908111) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"