Anti-Myeloperoxidase antibody [7,17] (FITC) (ab91237)

Overview

  • Product name
    Anti-Myeloperoxidase antibody [7,17] (FITC)
    See all Myeloperoxidase primary antibodies
  • Description
    Mouse monoclonal [7,17] to Myeloperoxidase (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Specificity
    ab91237 reacts with virtually all cells of the myeloid lineage (from myekloblast to neutrophils and monocytes). ab91237 does not react with Human lymphocytes, thrombocytes and erythrocytes. 96% of all AML's are found positive; 100% of all ALL's are found negative.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human myeloperoxidase from CML cells

  • Positive control
    • Normal Human peripheral blood

Properties

Applications

Our Abpromise guarantee covers the use of ab91237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use 20 µl for 106 cells.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
    • Involvement in disease
      Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
    • Sequence similarities
      Belongs to the peroxidase family. XPO subfamily.
    • Cellular localization
      Lysosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • 84 kDa myeloperoxidase antibody
      • 89 kDa myeloperoxidase antibody
      • EC 1.11.1.7 antibody
      • EC1.11.2.2 antibody
      • fj80f04 antibody
      • MPO antibody
      • mpx antibody
      • myeloid-specific peroxidase antibody
      • Myeloperoxidase antibody
      • Myeloperoxidase heavy chain antibody
      • Myeloperoxidase light chain antibody
      • PERM_HUMAN antibody
      • wu:fj80f04 antibody
      see all

    Images

    • ab91237, at 20 µl / 106 cells, staining Myeloperoxidase in normal Human peripheral blood, by Flow Cytometry.

    References

    ab91237 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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