Overview

  • Product name
    Anti-Myeloperoxidase antibody
    See all Myeloperoxidase primary antibodies
  • Description
    Rabbit polyclonal to Myeloperoxidase
  • Specificity
    Assay by immunoelectrophoresis resulted in a single precipitin arc against purified and partially purified Myeloperoxidase [Human White Cell].
  • Tested applications
    Suitable for: WB, ELISA, Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Myeloperoxidase [Human White Cell]

  • General notes
    The antibody is supplied as whole antiserum. The concentration listed is for total protein, and not IgG concentration.

Properties

Applications

Our Abpromise guarantee covers the use of ab2088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
Dot blot Use at an assay dependent concentration.

Target

  • Function
    Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
  • Involvement in disease
    Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
  • Sequence similarities
    Belongs to the peroxidase family. XPO subfamily.
  • Cellular localization
    Lysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 84 kDa myeloperoxidase antibody
    • 89 kDa myeloperoxidase antibody
    • EC 1.11.1.7 antibody
    • EC1.11.2.2 antibody
    • fj80f04 antibody
    • MPO antibody
    • mpx antibody
    • myeloid-specific peroxidase antibody
    • Myeloperoxidase antibody
    • Myeloperoxidase heavy chain antibody
    • Myeloperoxidase light chain antibody
    • PERM_HUMAN antibody
    • wu:fj80f04 antibody
    see all

References

This product has been referenced in:
  • Fecho K  et al. Effects of carrageenan and morphine on acute inflammation and pain in Lewis and Fischer rats. Brain Behav Immun 21:68-78 (2007). Read more (PubMed: 16603335) »

See 1 Publication for this product

Customer reviews and Q&As

This product has been assayed against 1.0 ug of Myeloperoxidase in a standard capture ELISA using Peroxidase Conjugated secondary antibody and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid]) as a substrate for 30 minutes at room temperatur...

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Approx. 84kDa (unprocessed precursor). Try this antibody at 1:1000 dilution and adjust it accordingly from the results obtained.

The anti-myeloperoxidase has only been tested against the antigen to which it was made. Reducing the antigen may destroy the epitopes generated by the whole molecule. Background bands can be reduced by trying a different blocking buffer, using a mor...

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This antibody has not been tested against rat myeloperoxidase. We can not find any commercial source of antibody specific to rat myeloperoxidase.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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