Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab106253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 27 kDa.

Target

  • FunctionInvolved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
  • Tissue specificitySkeletal muscle.
  • Involvement in diseaseDefects in MYF6 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bHLHc4 antibody
    • Class C basic helix-loop-helix protein 4 antibody
    • CNM3 antibody
    • HERCULIN antibody
    • MRF4 antibody
    • Muscle-regulatory factor 4 antibody
    • Muscle-specific regulatory factor 4 antibody
    • Myf-6 antibody
    • Myf6 antibody
    • MYF6_HUMAN antibody
    • myogenic factor 6 (herculin) antibody
    • Myogenic factor 6 antibody
    see all

Anti-MYF6 antibody images

  • Lane 1 : Anti-MYF6 antibody (ab106253) at 0.5 µg/ml
    Lane 2 : Anti-MYF6 antibody (ab106253) at 0.5 mg/ml
    Lane 3 : anti-MYC tag antibody at 1/1000 dilution

    Lane 1 : HEK293 lysate overexpressing Human MYF6 with MYC tag
    Lane 2 : Mock-transfected HEK293 lysate
    Lane 3 : HEK293 lysate overexpressing Human MYF6 with MYC tag

    Lysates/proteins at 10 µg per lane.

    Developed using the ECL technique

    Predicted band size : 27 kDa

References for Anti-MYF6 antibody (ab106253)

ab106253 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"