Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab64802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 27 kDa (predicted molecular weight: 27 kDa).
ELISA 1/20000.

Target

  • FunctionInvolved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
  • Tissue specificitySkeletal muscle.
  • Involvement in diseaseDefects in MYF6 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bHLHc4 antibody
    • Class C basic helix-loop-helix protein 4 antibody
    • CNM3 antibody
    • HERCULIN antibody
    • MRF4 antibody
    • Muscle-regulatory factor 4 antibody
    • Muscle-specific regulatory factor 4 antibody
    • Myf-6 antibody
    • Myf6 antibody
    • MYF6_HUMAN antibody
    • myogenic factor 6 (herculin) antibody
    • Myogenic factor 6 antibody
    see all

Anti-MYF6 antibody images

  • All lanes : Anti-MYF6 antibody (ab64802) at 1/500 dilution

    Lane 1 : Extracts from 293 cells at 5-30ug with no immunizing peptide
    Lane 2 : Extracts from HepG2 cells at 5-30ug with no immunizing peptide
    Lane 3 : Extracts from HepG2 cells at 5-30ug with immunizing peptide at 5-10ug


    Predicted band size : 27 kDa
    Observed band size : 27 kDa

References for Anti-MYF6 antibody (ab64802)

ab64802 has not yet been referenced specifically in any publications.

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