Overview

  • Product nameAnti-MYH antibody
    See all MYH primary antibodies
  • Description
    Goat polyclonal to MYH
  • SpecificityThis antibody is expected to recognise all reported isoforms (NP_036354.1; NP_001041636.1; NP_001041637.1; NP_001041638.1; NP_001041639.1).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-HISTDAHSLNSAAQ

    , corresponding to C terminal amino acids 533-546 of Human MYH

  • Positive control
    • Human Bone Marrow lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: antibody detection limit dilution 1/16000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
    • Involvement in diseaseDefects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.
      Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
    • Sequence similaritiesBelongs to the Nth/MutY family.
      Contains 1 nudix hydrolase domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • A/G specific adenine DNA glycosylase antibody
      • A/G-specific adenine DNA glycosylase antibody
      • Adenine DNA glycosylase antibody
      • CYP2C antibody
      • hMYH antibody
      • MGC4416 antibody
      • MutY (E. coli) homolog antibody
      • MutY homolog (E. coli) antibody
      • MutY homolog antibody
      • MutY, E. coli, homolog of antibody
      • Mutyh antibody
      • MUTYH_HUMAN antibody
      • MYH antibody
      • rMYH antibody
      see all

    Anti-MYH antibody images

    • Anti-MYH antibody (ab58572) at 0.1 µg/ml + Human Bone Marrow lysate at 35 µg

      Predicted band size : 61 kDa
      Observed band size : 61 kDa

    References for Anti-MYH antibody (ab58572)

    ab58572 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab58572.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"