Our Abpromise guarantee covers the use of ab75589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 228 kDa (predicted molecular weight: 228 kDa).


  • FunctionCellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
  • Tissue specificityHigh levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.
  • Involvement in diseaseDefects in MYH14 are the cause of deafness autosomal dominant type 4A (DFNA4A) [MIM:600652]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in MYH14 are the cause of peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH) [MIM:614369]. PNMHH is a complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
  • Sequence similaritiesContains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • DomainThe rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2400004E04Rik antibody
    • DFNA4 antibody
    • DKFZp667A1311 antibody
    • FLJ13881 antibody
    • FLJ43092 antibody
    • FP17425 antibody
    • II C antibody
    • KIAA2034 antibody
    • MHC16 antibody
    • Myh 14 antibody
    • MYH14 antibody
    • MYH14_HUMAN antibody
    • Myosin 14 antibody
    • Myosin antibody
    • Myosin heavy chain 14 antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain non muscle IIc antibody
    • Myosin heavy polypeptide 14 antibody
    • Myosin-14 antibody
    • NMHC II C antibody
    • NMHC II-C antibody
    • Non muscle myosin heavy chain IIc antibody
    • non-muscle IIc antibody
    • Non-muscle myosin heavy chain IIc antibody
    • Nonmuscle myosin heavy chain II C antibody
    • OTTMUSP00000019210 antibody
    see all

Anti-Myh14 antibody images

  • All lanes : Anti-Myh14 antibody (ab75589) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 228 kDa
    Observed band size : 228 kDa
    Additional bands at : 100 kDa,45 kDa,55 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 3 minutes

References for Anti-Myh14 antibody (ab75589)

ab75589 has not yet been referenced specifically in any publications.

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