Overview

  • Product nameAnti-MYLK2 antibody
    See all MYLK2 primary antibodies
  • Description
    Mouse monoclonal to MYLK2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: KLLAKKPPSE ASELTFEGVP MTHSPTDPRP AKAEEGKNIL AESQKEVGEK TPGQAGQAKM QGDTSRGIEF QAVPSEKSEV GQALCLTARE EDCFQILDDC , corresponding to amino acids 161-260 of Human MYLK2

Properties

Applications

Our Abpromise guarantee covers the use of ab57944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImplicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
    • Tissue specificityHeart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
    • Involvement in diseaseDefects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • Cellular localizationCytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
    • Information by UniProt
    • Database links
    • Alternative names
      • KMLC antibody
      • MLCK antibody
      • MLCK, skeletal/cardiac antibody
      • MLCK2 antibody
      • MYLK 2 antibody
      • MYLK2 antibody
      • MYLK2_HUMAN antibody
      • Myosin light chain kinase 2 antibody
      • Myosin light chain kinase 2 skeletal muscle antibody
      • Myosin light chain kinase 2 skeletal/cardiac muscle antibody
      • MYOSIN LIGHT POLYPEPTIDE KINASE antibody
      • Myosin light polypeptide kinase, skeletal/cardiac antibody
      • Skeletal muscle myosin light chain kinase antibody
      • Skeletal myosin light chain kinase antibody
      • skeletal/cardiac muscle antibody
      • skMLCK antibody
      see all

    Anti-MYLK2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57944 MYLK2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-MYLK2 antibody (ab57944)

    ab57944 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57944.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"