The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 190 kDa.
Use at an assay dependent dilution. PubMed: 19554350
FunctionProcessive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
Tissue specificityDetected in melanocytes.
Involvement in diseaseGriscelli syndrome 1 Griscelli syndrome 3 Elejalde syndrome
Sequence similaritiesBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Contains 1 dilute domain. Contains 6 IQ domains. Contains 1 myosin motor domain.
Lee C et al. Changes in localization and expression levels of Shroom2 and spectrin contribute to variation in amphibian egg pigmentation patterns. Dev Genes Evol219:319-30 (2009).
Other, Xenopus laevis
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