Anti-MYO5B antibody - N-terminal (ab190096)

Overview

  • Product name
    Anti-MYO5B antibody - N-terminal
    See all MYO5B primary antibodies
  • Description
    Rabbit polyclonal to MYO5B - N-terminal
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human MYO5B (N terminal). The exact sequence is proprietary. (NM_001080467)
    Database link: Q9ULV0

  • Positive control
    • Human skeletal muscle

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.2
    Preservative: 0.09% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab190096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2.5 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 214 kDa.

Target

  • Function
    May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
  • Involvement in disease
    Diarrhea 2, with microvillus atrophy
  • Sequence similarities
    Contains 1 dilute domain.
    Contains 6 IQ domains.
    Contains 1 myosin head-like domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA1119 antibody
    • Myo5b antibody
    • MYO5B_HUMAN antibody
    • Myosin Vb antibody
    • Unconventional myosin-Vb antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed paraffin embedded human skeletal muscle labeling MYO5B with ab190096 at 5 µg/ml

References

ab190096 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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