Overview

  • Product nameAnti-Myocilin antibody
    See all Myocilin primary antibodies
  • Description
    Mouse monoclonal to Myocilin
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human, Recombinant Fragment
  • Immunogen

    Recombinant fragment: QLRKANDQSG RCQYTFSVAS PNESSCPEQS QAMSVIHNLQ RDSSTQRLDL EATKARLSSL ESLLHQLTLD QAARPQETQE GLQRELGTLR RERDQLETQT , corresponding to amino acids 36-135 of Human Myocilin

Properties

Applications

Our Abpromise guarantee covers the use of ab55477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml.
IHC-P Use a concentration of 10 µg/ml.

Target

  • FunctionMay participate in the obstruction of fluid outflow in the trabecular meshwork.
  • Tissue specificityExpressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
  • Involvement in diseaseDefects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • Sequence similaritiesContains 1 olfactomedin-like domain.
  • Post-translational
    modifications
    Different isoforms may arise by post-translational modifications.
    Glycosylated.
    Palmitoylated.
  • Cellular localizationRough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • GLC1A antibody
    • GPOA antibody
    • JOAG antibody
    • JOAG1 antibody
    • Mutated trabecular meshwork-induced glucocorticoid response protein antibody
    • MYOC antibody
    • MYOC_HUMAN antibody
    • Myocilin antibody
    • Myocilin, trabecular meshwork inducible glucocorticoid antibody
    • TIGR antibody
    • Trabecular meshwork induced glucocorticoid response protein antibody
    • Trabecular meshwork-induced glucocorticoid response protein antibody
    see all

Anti-Myocilin antibody images

  • Western blot against tagged recombinant protein immunogen using ab55477 Myocilin antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

  • ab55477 at 10 ug/ml staining Myocilin in human small intestine tissue sections by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded sections).

References for Anti-Myocilin antibody (ab55477)

ab55477 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab55477.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"