Anti-Myosin light chain 3 antibody [EPR4161] (ab108516)

Overview

  • Product nameAnti-Myosin light chain 3 antibody [EPR4161]
    See all Myosin light chain 3 primary antibodies
  • Description
    Rabbit monoclonal [EPR4161] to Myosin light chain 3
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human Myosin light chain 3.

  • Positive control
    • Human skeletal muscle, Human heart, Mouse heart, Mouse liver, and Rat heart lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab108516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionRegulatory light chain of myosin. Does not bind calcium.
    • Involvement in diseaseDefects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
      Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
    • Sequence similaritiesContains 3 EF-hand domains.
    • Post-translational
      modifications
      The N-terminus is blocked.
      N-terminus is methylated by METTL11A/NTM1.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cardiac myosin light chain 1 antibody
      • CMH8 antibody
      • CMLC1 antibody
      • ELC of myosin antibody
      • Essential light chain of myosin antibody
      • MLC1SB antibody
      • MLC1V antibody
      • MYL3 antibody
      • MYL3_HUMAN antibody
      • Myosin light chain 1 antibody
      • Myosin light chain 1 slow twitch muscle B/ventricular isoform antibody
      • Myosin light chain 1 slow, B antibody
      • Myosin light chain 3 antibody
      • Myosin, light chain 1, ventricular antibody
      • myosin, light chain 3, alkali; ventricular, skeletal, slow antibody
      • myosin, light polypeptide 3, alkali antibody
      • myosin, light polypeptide 3, alkali; ventricular, skeletal, slow antibody
      • OTTHUMP00000165922 antibody
      • Slow skeletal ventricular myosin alkali light chain 3 antibody
      • slow-twitch muscle B/ventricular isoform antibody
      • Ventricular/slow twitch myosin alkali light chain antibody
      • VLC1 antibody
      see all

    Anti-Myosin light chain 3 antibody [EPR4161] images

    • All lanes : Anti-Myosin light chain 3 antibody [EPR4161] (ab108516) at 1/1000 dilution

      Lane 1 : Human skeletal muscle lysate
      Lane 2 : Human heart lysate
      Lane 3 : Mouse heart lysate
      Lane 4 : Mouse liver lysate
      Lane 5 : Rat heart lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 22 kDa

    References for Anti-Myosin light chain 3 antibody [EPR4161] (ab108516)

    ab108516 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"