Overview

  • Product nameAnti-Myozenin 2 antibody
    See all Myozenin 2 primary antibodies
  • Description
    Mouse polyclonal to Myozenin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human Myozenin 2 (AAH05195)

  • Positive control
    • Myozenin 2 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab89148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 30 kDa.

Target

  • FunctionMyozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
  • Tissue specificityExpressed specifically in heart and skeletal muscle.
  • Involvement in diseaseDefects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16) [MIM:613838]. CMH16 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similaritiesBelongs to the myozenin family.
  • Cellular localizationCytoplasm > myofibril > sarcomere > Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.
  • Information by UniProt
  • Database links
  • Alternative names
    • C4orf5 antibody
    • Calcineurin binding protein calsarcin 1 antibody
    • Calsarcin 1 antibody
    • Calsarcin-1 antibody
    • Calsarcin1 antibody
    • CMH16 antibody
    • CS 1 antibody
    • CS1 antibody
    • FATZ related protein 2 antibody
    • FATZ-related protein 2 antibody
    • Muscle specific protein antibody
    • MYOZ 2 antibody
    • MYOZ2 antibody
    • MYOZ2_HUMAN antibody
    • Myozenin-2 antibody
    • Myozenin2 antibody
    see all

Anti-Myozenin 2 antibody images

  • All lanes : Anti-Myozenin 2 antibody (ab89148) at 1/500 dilution

    Lane 1 : Myozenin 2 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 30 kDa
    Observed band size : 30 kDa

References for Anti-Myozenin 2 antibody (ab89148)

ab89148 has not yet been referenced specifically in any publications.

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