Overview

  • Product name
  • Description
    Rabbit polyclonal to MYSM1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide between amino acids 118-147 from the N-terminal region of Human MYSM1 (NP_001078956.1)

  • Positive control
    • MDA-MB231 cell lysate Mouse kidney tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab107542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 95 kDa.

Target

  • Function
    Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
  • Sequence similarities
    Belongs to the peptidase M67A family. MYSM1 subfamily.
    Contains 1 MPN (JAB/Mov34) domain.
    Contains 1 SANT domain.
    Contains 1 SWIRM domain.
  • Domain
    Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2A-DUB antibody
    • 2ADUB antibody
    • Histone H2A deubiquitinase antibody
    • Histone H2A deubiquitinase MYSM1 antibody
    • KIAA1915 antibody
    • Myb like SWIRM and MPN domains 1 antibody
    • Myb like, SWIRM and MPN domain containing protein antibody
    • Myb like, SWIRM and MPN domains 1 antibody
    • Myb-like antibody
    • Myb-like, SWIRM and MPN domains 1 antibody
    • MYSM 1 antibody
    • mysm1 antibody
    • MYSM1 Myb-like, SWIRM and MPN domains 1 antibody
    • MYSM1_HUMAN antibody
    • RP4-592A1.1 antibody
    • SWIRM and MPN domain-containing protein 1 antibody
    see all

Images

  • Anti-MYSM1 antibody (ab107542) at 1/100 dilution + MDA-MB231 cell lysate at 35 µg

    Predicted band size : 95 kDa
  • Anti-MYSM1 antibody (ab107542) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

    Predicted band size : 95 kDa

References

ab107542 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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