Overview

  • Product name
  • Description
    Rabbit polyclonal to MYSM1
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Chimpanzee, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 700-750 of Human MYSM1 (NP_001078956.1).

  • Positive control
    • Jurkat whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab110109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
    • Sequence similarities
      Belongs to the peptidase M67A family. MYSM1 subfamily.
      Contains 1 MPN (JAB/Mov34) domain.
      Contains 1 SANT domain.
      Contains 1 SWIRM domain.
    • Domain
      Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2A-DUB antibody
      • 2ADUB antibody
      • Histone H2A deubiquitinase antibody
      • Histone H2A deubiquitinase MYSM1 antibody
      • KIAA1915 antibody
      • Myb like SWIRM and MPN domains 1 antibody
      • Myb like, SWIRM and MPN domain containing protein antibody
      • Myb like, SWIRM and MPN domains 1 antibody
      • Myb-like antibody
      • Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM 1 antibody
      • mysm1 antibody
      • MYSM1 Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM1_HUMAN antibody
      • RP4-592A1.1 antibody
      • SWIRM and MPN domain-containing protein 1 antibody
      see all

    Images

    • Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    References

    ab110109 has not yet been referenced specifically in any publications.

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