The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at 2-5 µg/mg of lysate.
Application notesIs unsuitable for WB.
FunctionMetalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Sequence similaritiesBelongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain.
DomainBinds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Myb like, SWIRM and MPN domain containing protein antibody
Myb like, SWIRM and MPN domains 1 antibody
Myb-like, SWIRM and MPN domains 1 antibody
MYSM 1 antibody
MYSM1 Myb-like, SWIRM and MPN domains 1 antibody
SWIRM and MPN domain-containing protein 1 antibody
Anti-MYSM1 antibody images
Immunoprecipitation - MYSM1 antibody (ab110109)
Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.
References for Anti-MYSM1 antibody (ab110109)
has not yet been referenced specifically in any publications.
Publishing research using ab110109? Please let us know so that we can cite the reference in this datasheet.
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