Overview

  • Product nameAnti-MYSM1 antibody
    See all MYSM1 primary antibodies
  • Description
    Rabbit polyclonal to MYSM1
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Chimpanzee, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 700-750 of Human MYSM1 (NP_001078956.1).

  • Positive control
    • Jurkat whole cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab110109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionMetalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
    • Sequence similaritiesBelongs to the peptidase M67A family. MYSM1 subfamily.
      Contains 1 MPN (JAB/Mov34) domain.
      Contains 1 SANT domain.
      Contains 1 SWIRM domain.
    • DomainBinds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2A-DUB antibody
      • 2ADUB antibody
      • Histone H2A deubiquitinase antibody
      • Histone H2A deubiquitinase MYSM1 antibody
      • KIAA1915 antibody
      • Myb like SWIRM and MPN domains 1 antibody
      • Myb like, SWIRM and MPN domain containing protein antibody
      • Myb like, SWIRM and MPN domains 1 antibody
      • Myb-like antibody
      • Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM 1 antibody
      • mysm1 antibody
      • MYSM1 Myb-like, SWIRM and MPN domains 1 antibody
      • MYSM1_HUMAN antibody
      • RP4-592A1.1 antibody
      • SWIRM and MPN domain-containing protein 1 antibody
      see all

    Anti-MYSM1 antibody images

    • Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    References for Anti-MYSM1 antibody (ab110109)

    ab110109 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab110109.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"