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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper
Overview
Product name
Anti-n-Myc antibody
See all n-Myc products (4) ...
Description
Rabbit polyclonal to n-Myc
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Rat, Dog
Immunogen
Synthetic peptide: SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE, corresponding to a region within C terminal amino acids 361-410 of Human n-Myc
SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE
Positive control
Fetal heart lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
-
Western blot - n-Myc antibody (ab24339)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab24339 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 2.5 µg/mlDetects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).
Target
Function
May function as a transcription factor.
Involvement in disease
Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Defects in MYCN are the cause of microcephaly-oculo-digito-esophageal-duodenal syndrome (MODED) [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Microcephaly-oculo-digito-esophageal-duodenal syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence (MCPHDANI) [MIM:602585].
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Developmental stage
Expressed during fetal development.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP04198
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- bHLHe37 antibody
- Class E basic helix-loop-helix protein 37 antibody
- MODED antibody
see all
Database links
- Entrez Gene: 4613 Human
- Entrez Gene: 298894 Rat
- Omim: 164840 Human
- SwissProt: P04198 Human
- SwissProt: Q63379 Rat
- Unigene: 25960 Human
- Unigene: 81116 Rat
Anti-n-Myc antibody images:
Western blot - n-Myc antibody (ab24339)
Anti-n-Myc antibody (ab24339) at 2.5 µg/ml + Fetal heart lysate
Secondary
HRP-conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 50 kDa
Observed band size : 50 kDa
References for Anti-n-Myc antibody (ab24339)
ab24339 has not yet been referenced specifically in any publications.
Publishing research using ab24339? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"