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Anti-n-Myc antibody (ab24339)

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Overview

Product name

Anti-n-Myc antibody
See all n-Myc products (4) ...

Description

Rabbit polyclonal to n-Myc

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Rat, Dog

Immunogen

Synthetic peptide: SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE, corresponding to a region within C terminal amino acids 361-410 of Human n-Myc

SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE

Positive control

Fetal heart lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 2% Sucrose, PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - n-Myc antibody (ab24339)Western blot - n-Myc antibody (ab24339) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24339 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 2.5 µg/mlDetects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

Target

Function

May function as a transcription factor.

Involvement in disease

Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Defects in MYCN are the cause of microcephaly-oculo-digito-esophageal-duodenal syndrome (MODED) [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Microcephaly-oculo-digito-esophageal-duodenal syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence (MCPHDANI) [MIM:602585].

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Developmental stage

Expressed during fetal development.

Cellular localization

Nucleus.

Target information above from: UniProt accessionP04198 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • bHLHe37 antibody
  • Class E basic helix-loop-helix protein 37 antibody
  • MODED antibody
  • MYCN antibody
  • MYCN_HUMAN antibody
  • N myc antibody
  • N myc proto oncogene protein antibody
  • N-myc proto-oncogene protein antibody
  • Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene antibody
  • Neuroblastoma MYC oncogene antibody
  • NMYC antibody
  • NMYC proto oncogene protein antibody
  • ODED antibody
  • Oncogene NMYC antibody
  • pp65/67 antibody
  • v myc avian myelocytomatosis viral related oncogene neuroblastoma derived antibody
  • v myc myelocytomatosis viral related oncogene neuroblastoma derived antibody
see all

Anti-n-Myc antibody images:

  Western blot - n-Myc antibody (ab24339)

Western blot - n-Myc antibody (ab24339)

Anti-n-Myc antibody (ab24339) at 2.5 µg/ml + Fetal heart lysate

Secondary
HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

Predicted band size : 50 kDa
Observed band size : 50 kDa

References for Anti-n-Myc antibody (ab24339)

ab24339 has not yet been referenced specifically in any publications.

Publishing research using ab24339? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"