Biological descriptionSelective A1 receptor agonist (EC50 = 8.2 nM). Adenosine analogue; exerts anticonvulsant effects and protects against neuronal death.
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Heidarianpour A et al. Anticonvulsant effects of N6-cyclohexyladenosine microinjected into the CA1 region of the hippocampus on entorhinal cortex-kindled seizures in rats. Epileptic Disord8:259-66 (2006).
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Santicioli P et al. Adenosine A1 receptors mediate the presynaptic inhibition of calcitonin gene-related peptide release by adenosine in the rat spinal cord. Eur J Pharmacol231:139-42 (1993).
Read more (PubMed: 8444279) »
von Lubitz DK et al. Cyclohexyl adenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus. Stroke19:1133-9 (1988).
Read more (PubMed: 3413811) »