Overview

  • Product name
  • Description
    Rabbit polyclonal to Nac1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Cow, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 297-524 of Human Nac1 (Uniprot ID: Q96RE7).

  • Positive control
    • Mouse olfactory whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab151426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.

Target

  • Function
    Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
  • Tissue specificity
    Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
  • Sequence similarities
    Contains 1 BEN domain.
    Contains 1 BTB (POZ) domain.
  • Cellular localization
    Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.
  • Information by UniProt
  • Database links
  • Alternative names
    • BEND8 antibody
    • BTB Domain Containing 14B antibody
    • BTB/POZ domain-containing protein 14B antibody
    • btbd14b antibody
    • FLJ37383 antibody
    • NAC-1 antibody
    • NAC1 antibody
    • Nacc1 antibody
    • NACC1_HUMAN antibody
    • Nucleus accumbens-associated protein 1 antibody
    see all

Images

  • Anti-Nac1 antibody (ab151426) at 1/3000 dilution + Mouse olfactory whole cell lysate at 50 µg

    Predicted band size : 57 kDa

References

ab151426 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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