Overview

  • Product name
  • Description
    Goat polyclonal to Nac1
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Dog, Chimpanzee, Rhesus monkey, Opossum
  • Immunogen

    Synthetic peptide:

    KTEQQESDSVQC

    , corresponding to internal sequence amino acids 167-178 of Human Nac1

  • Positive control
    • Bone Marrow lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab60264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1/2000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
    • Tissue specificity
      Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
    • Sequence similarities
      Contains 1 BEN domain.
      Contains 1 BTB (POZ) domain.
    • Cellular localization
      Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.
    • Information by UniProt
    • Database links
    • Alternative names
      • BEND8 antibody
      • BTB Domain Containing 14B antibody
      • BTB/POZ domain-containing protein 14B antibody
      • btbd14b antibody
      • FLJ37383 antibody
      • NAC-1 antibody
      • NAC1 antibody
      • Nacc1 antibody
      • NACC1_HUMAN antibody
      • Nucleus accumbens-associated protein 1 antibody
      see all

    Images

    • ab60264 antibody (0.5µg/ml) staining of Nac1 in Human Bone Marrow lysate (35µg protein in RIPA buffer)

      Predicted band size : 57 kDa
      Observed band size : 57 kDa

    References

    ab60264 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab60264.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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