The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 µg/ml.
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 13 kDa).
FunctionMay be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Tissue specificityFound in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.
Sequence similaritiesBelongs to the BEX family.
DomainThe nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.
Post-translational modificationsUbiquitinated. Degraded by the proteasome.
Cellular localizationNucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
ab21303 at 2µg/ml staining NADE in human brain tissue by IHC
References for Anti-NADE antibody (ab21303)
This product has been referenced in:
Xiao L & Tsutsui T Three-dimensional epithelial and mesenchymal cell co-cultures form early tooth epithelium invagination-like structures: Expression patterns of relevant molecules. J Cell Biochem : (2012).
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