Overview

  • Product name
    Nafcillin sodium
  • Description
    Narrow spectrum beta-lactam antibiotic agent
  • Biological description
    Narrow spectrum beta-lactam antibiotic agent. Binds to PBP and inhibits bacterial cell wall synthesis. Resists staphylococcal penicillinase inactivation. Shows bactericidal effects against penicillin-susceptible strains in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    (2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt
  • Molecular weight
    436.46
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H21N2NaO5S
  • CAS Number
    7177-50-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Sakoulas G  et al. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl) 92:139-49 (2014). Read more (PubMed: 24297496) »
  • Wolf KK  et al. Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport. Toxicol In Vitro 24:297-309 (2010). Read more (PubMed: 19706322) »
  • Kernodle DS  et al. Growth of Staphylococcus aureus with nafcillin in vitro induces alpha-toxin production and increases the lethal activity of sterile broth filtrates in a murine model. J Infect Dis 172:410-9 (1995). Read more (PubMed: 7542686) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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