Naloxone hydrochloride, Opioid antagonist (ab120074)
Key features and details
- Opioid antagonist
- CAS Number: 357-08-4
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Naloxone hydrochloride, Opioid antagonist -
Description
Opioid antagonist -
Biological description
Competitive opioid antagonist.
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CAS Number
357-08-4 -
Chemical structure
Properties
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Chemical name
(5α)-4,5-Epoxy-3,14-dihydro-17(2-propenyl)morphinan-6-one hydrochloride -
Molecular weight
363.84 -
Molecular formula
C19H21NO4.HCl -
PubChem identifier
5464092 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120074 has been referenced in 4 publications.
- Liu S et al. Effect of endomorphin-2 on orofacial pain induced by orthodontic tooth movement in rats. Eur J Oral Sci 127:408-416 (2019). PubMed: 31365768
- Birdsong WT et al. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8:N/A (2019). PubMed: 31099753
- Arttamangkul S et al. Cellular tolerance at the µ-opioid receptor is phosphorylation dependent. Elife 7:N/A (2018). PubMed: 29589831
- Charlet A et al. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine. Mol Pain 6:96 (2010). PubMed: 21172011