Overview

  • Product name
  • Description
    Rabbit polyclonal to NALP12
  • Specificity
    Multiple isoforms of NALP12 are known to exist. ab105409 is predicted to not cross-react with other NALP family members.
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    An 18 amino acid peptide from near the N terminus of Human NALP12 (NP_653288).

  • Positive control
    • Human brain tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 120 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
  • Tissue specificity
    Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
  • Involvement in disease
    Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
  • Sequence similarities
    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.3 antibody
    • FCAS2 antibody
    • Monarch 1 antibody
    • Monarch-1 antibody
    • NACHT, leucine rich repeat and PYD containing 12 antibody
    • NACHT, LRR and PYD containing protein 12 antibody
    • NACHT, LRR and PYD domains-containing protein 12 antibody
    • NAL12_HUMAN antibody
    • NLR family, pyrin domain containing 12 antibody
    • NLRP12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
    • OTTHUMP00000067227 antibody
    • PAN6 antibody
    • PYPAF7 antibody
    • PYRIN containing APAF1 like protein 7 antibody
    • PYRIN-containing APAF1-like protein 7 antibody
    • Regulated by nitric oxide antibody
    • RNO antibody
    • RNO2 antibody
    see all

Images

  • Immunofluorescence of NALP12 in Human brain tissue with ab105409 at 20 ug/mL.

  • Immunohistochemistry of Human brain tissue with ab105409 5 μg/mL.

  • Anti-NALP12 antibody (ab105409) at 1 µg/ml + Human brain tissue lysate at 15 µg

    Predicted band size : 120 kDa

References

ab105409 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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