Overview

  • Product nameAnti-NALP12 antibody
    See all NALP12 primary antibodies
  • Description
    Mouse monoclonal to NALP12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-110 of Human NALP12

Properties

Applications

Our Abpromise guarantee covers the use of ab57906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
    • Tissue specificityDetected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
    • Involvement in diseaseDefects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
    • Sequence similaritiesBelongs to the NLRP family.
      Contains 1 DAPIN domain.
      Contains 8 LRR (leucine-rich) repeats.
      Contains 1 NACHT domain.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CLR19.3 antibody
      • FCAS2 antibody
      • Monarch 1 antibody
      • Monarch-1 antibody
      • NACHT, leucine rich repeat and PYD containing 12 antibody
      • NACHT, LRR and PYD containing protein 12 antibody
      • NACHT, LRR and PYD domains-containing protein 12 antibody
      • NAL12_HUMAN antibody
      • NLR family, pyrin domain containing 12 antibody
      • NLRP12 antibody
      • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
      • OTTHUMP00000067227 antibody
      • PAN6 antibody
      • PYPAF7 antibody
      • PYRIN containing APAF1 like protein 7 antibody
      • PYRIN-containing APAF1-like protein 7 antibody
      • Regulated by nitric oxide antibody
      • RNO antibody
      • RNO2 antibody
      see all

    Anti-NALP12 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57906 NALP12 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    References for Anti-NALP12 antibody (ab57906)

    This product has been referenced in:
    • Ataide MA  et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014). Read more (PubMed: 24453977) »

    See 1 Publication for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"