Overview

  • Product nameAnti-NALP12 antibody
    See all NALP12 primary antibodies
  • Description
    Rabbit polyclonal to NALP12
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the C terminal region of Human NLRP12 (NP_150639).

  • Positive control
    • HL-60 cell line lysate; Mouse testis tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab93113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 120 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
    • Tissue specificityDetected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
    • Involvement in diseaseDefects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
    • Sequence similaritiesBelongs to the NLRP family.
      Contains 1 DAPIN domain.
      Contains 8 LRR (leucine-rich) repeats.
      Contains 1 NACHT domain.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CLR19.3 antibody
      • FCAS2 antibody
      • Monarch 1 antibody
      • Monarch-1 antibody
      • NACHT, leucine rich repeat and PYD containing 12 antibody
      • NACHT, LRR and PYD containing protein 12 antibody
      • NACHT, LRR and PYD domains-containing protein 12 antibody
      • NAL12_HUMAN antibody
      • NLR family, pyrin domain containing 12 antibody
      • NLRP12 antibody
      • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
      • OTTHUMP00000067227 antibody
      • PAN6 antibody
      • PYPAF7 antibody
      • PYRIN containing APAF1 like protein 7 antibody
      • PYRIN-containing APAF1-like protein 7 antibody
      • Regulated by nitric oxide antibody
      • RNO antibody
      • RNO2 antibody
      see all

    Anti-NALP12 antibody images

    • All lanes : Anti-NALP12 antibody (ab93113) at 1/100 dilution

      Lane 1 : HL-60 cell line lysate
      Lane 2 : Mouse testis tissue lysate

      Lysates/proteins at 35 µg per lane.


      Predicted band size : 120 kDa

    References for Anti-NALP12 antibody (ab93113)

    ab93113 has not yet been referenced specifically in any publications.

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