Overview

  • Product name
    Anti-NALP12 antibody - Carboxyterminal end
    See all NALP12 primary antibodies
  • Description
    Rabbit polyclonal to NALP12 - Carboxyterminal end
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    This information is considered to be commercially sensitive

  • Positive control
    • Human prostate carcinoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Ammonium Sulphate Precipitation
  • Purification notes
    ab64928 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab64928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • Function
    May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
  • Tissue specificity
    Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
  • Involvement in disease
    Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
  • Sequence similarities
    Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.3 antibody
    • FCAS2 antibody
    • Monarch 1 antibody
    • Monarch-1 antibody
    • NACHT, leucine rich repeat and PYD containing 12 antibody
    • NACHT, LRR and PYD containing protein 12 antibody
    • NACHT, LRR and PYD domains-containing protein 12 antibody
    • NAL12_HUMAN antibody
    • NLR family, pyrin domain containing 12 antibody
    • NLRP12 antibody
    • Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody
    • OTTHUMP00000067227 antibody
    • PAN6 antibody
    • PYPAF7 antibody
    • PYRIN containing APAF1 like protein 7 antibody
    • PYRIN-containing APAF1-like protein 7 antibody
    • Regulated by nitric oxide antibody
    • RNO antibody
    • RNO2 antibody
    see all

Images

  • ab64928 at 1/10 dilution, staining NALP12 in human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.

References

This product has been referenced in:
  • Ataide MA  et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014). Read more (PubMed: 24453977) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab64928.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up