Overview

  • Product nameAnti-NALP2 antibody
    See all NALP2 primary antibodies
  • Description
    Rabbit polyclonal to NALP2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.

  • Positive control
    • PC-3 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab36850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 96 kDa (predicted molecular weight: 121 kDa).

Target

  • FunctionSuppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificityExpressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • Sequence similaritiesBelongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • DomainThe DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLR19.9 antibody
    • FLJ20510 antibody
    • Leucine rich repeat and PYD containing protein 2 antibody
    • LRR and PYD domains-containing protein 2 antibody
    • NACHT antibody
    • NACHT domain antibody
    • NACHT leucine rich repeat and PYD containing 2 antibody
    • NACHT LRR and PYD domains containing protein 2 antibody
    • NALP2 antibody
    • NALP2_HUMAN antibody
    • NBS1 antibody
    • NLR family pyrin domain containing 2 antibody
    • NLRP2 antibody
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody
    • Nucleotide-binding site protein 1 antibody
    • PAN1 antibody
    • PYPAF2 antibody
    • PYRIN containing APAF1 like protein2 antibody
    • PYRIN domain and NACHT domain-containing protein 1 antibody
    • PYRIN-containing APAF1-like protein 2 antibody
    see all

Anti-NALP2 antibody images

References for Anti-NALP2 antibody (ab36850)

This product has been referenced in:
  • Ji S  et al. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun 77:1044-52 (2009). WB ; Human . Read more (PubMed: 19103770) »

See 1 Publication for this product

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