Anti-Nanos Homologue 1 (NANOS1) antibody - Aminoterminal end (ab76567)


  • Product nameAnti-Nanos Homologue 1 (NANOS1) antibody - Aminoterminal end
    See all Nanos Homologue 1 (NANOS1) primary antibodies
  • Description
    Rabbit polyclonal to Nanos Homologue 1 (NANOS1) - Aminoterminal end
  • Tested applicationsSuitable for: IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the N-terminal region of human NANOS1 conjugated to KLH

  • Positive control
    • Human testis tissue


Associated products


Our Abpromise guarantee covers the use of ab76567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
ELISA 1/1000.


  • FunctionMay act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
  • Tissue specificityTestis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
  • Sequence similaritiesBelongs to the nanos family.
    Contains 1 nanos-type zinc finger.
  • Developmental stageFetal ovary and fetal testis (at protein level).
  • DomainThe Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
    The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
  • Cellular localizationCytoplasm > perinuclear region. Cytoplasm. Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC Rep1a antibody
    • EC_Rep1a antibody
    • NANO1_HUMAN antibody
    • NANOS 1 antibody
    • Nanos homolog 1 (Drosophila) antibody
    • Nanos homolog 1 antibody
    • NANOS1 antibody
    • Nos 1 antibody
    • NOS-1 antibody
    • Nos1 antibody
    • OTTHUMP00000046853 antibody
    • Rep 1a antibody
    • Rep1a antibody
    see all

Anti-Nanos Homologue 1 (NANOS1) antibody - Aminoterminal end images

  • Formalin-fixed and paraffin-embedded human testis tissue, stained with ab76567, at 1/10 dilution, followed by treatment with a peroxidase-conjugated secondary antibody and DAB staining.

References for Anti-Nanos Homologue 1 (NANOS1) antibody - Aminoterminal end (ab76567)

ab76567 has not yet been referenced specifically in any publications.

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