Nanos Homologue 1 (NANOS1) peptide (281-292) (ab45711)

Overview

  • Product name
    Nanos Homologue 1 (NANOS1) peptide (281-292)

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-SARDGPPGKKLR
    • Amino acids
      281 to 292

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Nanos Homologue 1 (NANOS1) antibody (ab36163)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • EC Rep1a
    • EC_Rep1a
    • NANO1_HUMAN
    • NANOS 1
    • Nanos homolog 1
    • Nanos homolog 1 (Drosophila)
    • NANOS1
    • Nos 1
    • NOS-1
    • Nos1
    • OTTHUMP00000046853
    • Rep 1a
    • Rep1a
    see all
  • Function
    May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
  • Tissue specificity
    Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
  • Sequence similarities
    Belongs to the nanos family.
    Contains 1 nanos-type zinc finger.
  • Developmental stage
    Fetal ovary and fetal testis (at protein level).
  • Domain
    The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
    The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
  • Cellular localization
    Cytoplasm > perinuclear region. Cytoplasm. Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
  • Information by UniProt

References for Nanos Homologue 1 (NANOS1) peptide (281-292) (ab45711)

ab45711 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45711.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up