• Product nameAnti-NANOS2 antibody
    See all NANOS2 primary antibodies
  • Description
    Rabbit polyclonal to NANOS2
  • Tested applicationsSuitable for: IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    KLH conjugated synthetic peptide selected from the C terminal region of human NANOS2.

  • Positive control
    • Human testis tissue



Our Abpromise guarantee covers the use of ab76568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
ELISA 1/1000.


  • FunctionPlays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
  • Tissue specificityTestis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
  • Sequence similaritiesBelongs to the nanos family.
    Contains 1 nanos-type zinc finger.
  • Developmental stageFetal ovary and fetal testis. Present in all germ cells of seminiferous tubules of the 24-week fetus (at protein level).
  • DomainThe Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Cellular localizationCytoplasm. Cytoplasm > P-body. Cytoplasm > perinuclear region. Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis.
  • Information by UniProt
  • Database links
  • Alternative names
    • NANO2_HUMAN antibody
    • Nanos homolog 2 antibody
    • Nanos homolog 2 Drosophila antibody
    • NANOS2 antibody
    • NOS-2 antibody
    • NOS2 antibody
    see all

Anti-NANOS2 antibody images

  • Formalin fixed and paraffin embedded human testis tissue stained with ab76568 at 1/10 dilution, followed by treatment with a peroxidase conjugated secondary antibody and DAB staining.

References for Anti-NANOS2 antibody (ab76568)

This product has been referenced in:
  • Santos Nassif Lacerda SM  et al. Phenotypic characterization and in vitro propagation and transplantation of the Nile tilapia (Oreochromis niloticus) spermatogonial stem cells. Gen Comp Endocrinol 192:95-106 (2013). Read more (PubMed: 23792279) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Mouse Cell (testis)
Permeabilization No
Specification testis
Blocking step Serum as blocking agent for 20 minute(s) · Concentration: 5% · Temperature: 23°C
Fixative Paraformaldehyde

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Submitted Apr 28 2016