Overview

  • Product name
    NASPM trihydrochloride
  • Description
    Selective, Ca2+-permeable AMPA receptor antagoinst
  • Biological description
    Selective, Ca2+-permeable AMPA receptor antagonist. Blocks GluR2 subunit lacking AMPA channels. Shows neuroprotective effects.

Properties

  • Chemical name
    N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide trihydrochloride
  • Molecular weight
    479.31
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H34N4O.3HCl
  • CAS Number
    1049731-36-3
  • PubChem identifier
    16219727
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Dong LD  et al. GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. J Neurosci 35:5409-21 (2015). Read more (PubMed: 25834064) »
  • Bender C  et al. Involvement of AMPA/kainate-excitotoxicity in MK801-induced neuronal death in the retrosplenial cortex. Neuroscience 169:720-32 (2010). Read more (PubMed: 20457221) »
  • Koike M  et al. Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res 29:27-36 (1997). Read more (PubMed: 9293490) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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