Overview

  • Product name
    Native Cyclosporin A protein
  • Protein length
    Full length protein

Description

  • Nature
    Native
  • Amino Acid Sequence
    • Species
      Beauveria
    • Sequence
      Chemically, cyclosporin is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl- L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydr oxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-alpha-amino-buty ryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-met hyl-L-leucyl). Molecular Formula: C62H111N11O12.
    • Molecular weight
      1 kDa
    • Additional sequence information
      Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64.

Specifications

Our Abpromise guarantee covers the use of ab73731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None

  • Reconstitution
    Reconstitute the lyophilized Cyclosporin A in sterile 18Megaohm-cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions

General Info

  • Relevance
    Cyclosporin is used to prevent rejection following solid organ and bone marrow transplantation . It has been estimated that cyclosporine is given to more than 90% of children who have received a kidney transplant in the United States. In addition, the ability of cyclosporin to inhibit T-cell activation has been shown to have a role in the treatment of diseases such as nephrotic syndrome, refractory Crohn's disease and ulcerative colitis, biliary cirrhosis, aplastic anemia, rheumatoid arthritis, myasthenia gravis, and dermatomyositis.
  • Cellular localization
    Cytoplasmic

References

ab73731 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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