Native Diphtheria Toxin (mutated G52 E) protein (ab188505)

Overview

  • Product name
    Native Diphtheria Toxin (mutated G52 E) protein
  • Protein length
    Full length protein

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
    • Species
      Corynebacterium diphtheriae
    • Molecular weight
      58 kDa
    • Amino acids
      1 to 536
    • Additional sequence information
      CRM197 non-toxic mutant (52nd Gly to Glu ) was highly purified from growth media of the Corynebacterium diphtheriae mutant as mostly unnicked form.

Specifications

Our Abpromise guarantee covers the use of ab188505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    Functional Studies

    SDS-PAGE

  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Additional notes

    CRM197 is a nontoxic mutant of Diphtheria toxin (Corynebacterium diphtheriae).

    This is mutant diphtheria toxin which can not kill cells but can bind the receptor molecule (HB-EGF receptor) on animal cells.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.20
    Constituents: 0.32% Tris HCl, 0.87% Sodium chloride

General Info

  • Alternative names
    • Corynebacterium diphtheriae toxoid
    • Diphtheria Toxin
    • tox
  • Relevance
    Corynebacterium diphtheriae is a gram-positive, nonmotile bacteria found in soil and animal feces. C. diphteriae infect the epithelial cells of the upper respiratory tract from where they produce and secrete a potent toxin. This toxin is absorbed and disseminated through lymph channels and blood to the susceptible tissues of the body.
  • Cellular localization
    Secreted

Images

  • SDS-PAGE analysis of ab188505.

References

ab188505 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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