Native human Lactate Dehydrogenase protein (ab77857)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Human
    • Additional sequence information
      Source: Human Erythrocytes (Red Blood Cells)

Specifications

Our Abpromise guarantee covers the use of ab77857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The activity (Units/mL) and specific activity (Units/mg) are unique to the lot, representative of how pure the lot is (higher purity = higher specific activity).

    One unit will catalyze the transformation of one micromole of L-lactate to pyruvate per minute at 37°C and pH 8.55.

     

     

  • Applications

    Western blot

    Functional Studies

  • Form
    Liquid
  • Additional notes

    Activity: 530 Units/mL @ 37°C Dimension
    Protein: 4.25 mg Protein/mL (Coomassie)
    One unit will catalyze the transformation of one micromole of L-lactate to pyruvate per minute at 37°C and

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C. Do Not Freeze.

    pH: 7.50
    Constituents: 0.0292% EDTA, 41% Ammonium sulphate, 0.15% DTT, 0.32% Tris HCl

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Cell proliferation-inducing gene 19 protein
    • GSD11
    • L lactate dehydrogenase B chain
    • L-lactate dehydrogenase A chain
    • Lactate dehydrogenase A
    • Lactate dehydrogenase B
    • Lactate dehydrogenase H chain
    • Lactate dehydrogenase M
    • LDH A
    • LDH B
    • LDH H
    • LDH heart subunit
    • LDH M
    • LDH muscle subunit
    • LDH-A
    • LDH-M
    • LDH1
    • ldha
    • LDHA_HUMAN
    • LDHBD
    • LDHM
    • MS1111
    • PIG19
    • Proliferation inducing gene 19
    • Renal carcinoma antigen NY REN 46
    • Renal carcinoma antigen NY-REN-59
    • TRG 5
    • TRG5
    see all
  • Pathway
    Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
  • Involvement in disease
    Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
  • Sequence similarities
    Belongs to the LDH/MDH superfamily. LDH family.
  • Post-translational
    modifications
    ISGylated.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References for Native human Lactate Dehydrogenase protein (ab77857)

ab77857 has not yet been referenced specifically in any publications.

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