Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab14357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/200 - 1/400. PubMed: 19399180
ICC 1/400.
WB 1/10000. Detects a band of approximately 117 kDa.
IHC-Fr Use at an assay dependent concentration. PubMed: 24782615

Target

  • FunctionReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
  • Involvement in diseaseDefects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
  • Sequence similaritiesBelongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AMDM antibody
    • ANP-B antibody
    • ANPB antibody
    • ANPR-B antibody
    • ANPRB antibody
    • ANPRB_HUMAN antibody
    • Atrial natriuretic peptide B type receptor antibody
    • Atrial natriuretic peptide receptor 2 antibody
    • Atrial natriuretic peptide receptor type B antibody
    • Atrionatriuretic peptide receptor B antibody
    • GC-B antibody
    • GCB antibody
    • Guanylate cyclase B antibody
    • GUC 2B antibody
    • GUC2B antibody
    • GUCY2B antibody
    • Natriuretic peptide receptor B antibody
    • Natriuretic peptide receptor B/guanylate cyclase B antibody
    • NPR-B antibody
    • Npr2 antibody
    • NPRB antibody
    • NPRBi antibody
    see all

References for Anti-Natriuretic Peptide Receptor B antibody (ab14357)

This product has been referenced in:
  • Lu HL  et al. Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice. World J Gastroenterol 20:4626-35 (2014). IHC-Fr ; Mouse . Read more (PubMed: 24782615) »
  • Abdelalim EM & Tooyama I BNP signaling is crucial for embryonic stem cell proliferation. PLoS One 4:e5341 (2009). ICC/IF ; Human, Rat . Read more (PubMed: 19399180) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"