The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/200 - 1/400. PubMed: 19399180
1/10000. Detects a band of approximately 117 kDa.
Use at an assay dependent concentration. PubMed: 24782615
FunctionReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Involvement in diseaseDefects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
Sequence similaritiesBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Post-translational modificationsPhosphorylation of the protein kinase-like domain is required for full activation by CNP.
Atrial natriuretic peptide B type receptor antibody
Atrial natriuretic peptide receptor 2 antibody
Atrial natriuretic peptide receptor type B antibody
Atrionatriuretic peptide receptor B antibody
Guanylate cyclase B antibody
GUC 2B antibody
Natriuretic peptide receptor B antibody
Natriuretic peptide receptor B/guanylate cyclase B antibody
References for Anti-Natriuretic Peptide Receptor B antibody (ab14357)
This product has been referenced in:
Lu HL et al. Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice. World J Gastroenterol20:4626-35 (2014).
Read more (PubMed: 24782615) »
Abdelalim EM & Tooyama I BNP signaling is crucial for embryonic stem cell proliferation. PLoS One4:e5341 (2009).
Read more (PubMed: 19399180) »