Anti-Natriuretic Peptide Receptor B antibody (ab55718)

Overview

  • Product nameAnti-Natriuretic Peptide Receptor B antibody
    See all Natriuretic Peptide Receptor B primary antibodies
  • Description
    Mouse monoclonal to Natriuretic Peptide Receptor B
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: AKNDHYRTLV RTGPSAPKLG EFVVTLHGHF NWTARAALLY LDARTDDRPH YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL , corresponding to amino acids 131-231 of Human Natriuretic Peptide Receptor B

Properties

Applications

Our Abpromise guarantee covers the use of ab55718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
    • Involvement in diseaseDefects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
    • Sequence similaritiesBelongs to the adenylyl cyclase class-4/guanylyl cyclase family.
      Contains 1 guanylate cyclase domain.
      Contains 1 protein kinase domain.
    • Post-translational
      modifications
      Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AMDM antibody
      • ANP-B antibody
      • ANPB antibody
      • ANPR-B antibody
      • ANPRB antibody
      • ANPRB_HUMAN antibody
      • Atrial natriuretic peptide B type receptor antibody
      • Atrial natriuretic peptide receptor 2 antibody
      • Atrial natriuretic peptide receptor type B antibody
      • Atrionatriuretic peptide receptor B antibody
      • GC-B antibody
      • GCB antibody
      • Guanylate cyclase B antibody
      • GUC 2B antibody
      • GUC2B antibody
      • GUCY2B antibody
      • Natriuretic peptide receptor B antibody
      • Natriuretic peptide receptor B/guanylate cyclase B antibody
      • NPR-B antibody
      • Npr2 antibody
      • NPRB antibody
      • NPRBi antibody
      see all

    Anti-Natriuretic Peptide Receptor B antibody images

    • Natriuretic Peptide Receptor B antibody (ab55718) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.
    • Western blot against tagged recombinant protein immunogen using ab55718 Natriuretic Peptide Receptor B antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Natriuretic Peptide Receptor B antibody (ab55718)

    ab55718 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"