Overview

  • Product nameNatural AGE protein
  • Protein lengthFull length protein

Description

  • NatureNatural
  • SourceNative

Associated products

Specifications

Our Abpromise guarantee covers the use of ab51995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity> 95 % SDS-PAGE.
    Purity > 98% 0.22 µm filter sterilized.
  • FormLiquid
  • Additional notesMay precipitate during extended storage. Sonicate to solubilize the precipitates. The AGE modified BSA was produced by reacting BSA with glycolaldehyde under sterile conditions followed by extensive dialysis and purification steps. Fluorescence of AGEs was confirmed by fluorescence spectrophotometry with Ex./Em. = 370/440 nm. Glycated BSA shows a 7000% increase in fluorescence in compared to control BSA.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • Advanced glycation end products
    • AGEs
  • RelevanceThe non enzymatic reaction of reducing carbohydrates with lysine side chains and N terminal amino groups of macromolecules (amino acids, proteins, phospholipids and nucleic acids) is called the Maillard reaction or glycation. The latter products of this process, termed advanced glycation end products (AGEs), adversely affect the functional properties of proteins, lipids and DNA. In long lived tissue proteins, these chemical modifications accumulate with age and may contribute to the pathophysiology of ageing and long term complications of diabetes, atherosclerosis and renal failure.
  • Cellular localizationCell Membrane and Secreted

References for Natural AGE protein (ab51995)

ab51995 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"