Overview

  • Product name
    Natural cow Aprotinin protein
  • Protein length
    Full length protein

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Cow
    • Additional sequence information
      Source of protein = Bovine lung

Specifications

Our Abpromise guarantee covers the use of ab49828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Biological activity is 6 x 106 IU/mg.
  • Applications

    Inhibition Assay

  • Purity
    > 95 % SDS-PAGE.
    Aprotinin is purified by proprietary chromatographic techniques. >98% by SDS-PAGE and HPLC analyses.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Add 1% BSA for extra stability. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Endotoxin level is <0.1 ng per µg of Aprotinin.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute with 1ml water for a concentration of 1mg/ml.

General Info

  • Alternative names
    • Basic protease inhibitor
    • BPI
    • BPTI
    • Pancreatic trypsin inhibitor
    • PTI
    see all
  • Relevance
    Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, Aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges.
  • Cellular localization
    Secreted

References

ab49828 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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