The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesConcentartion varies from lot to lot but is between 5-10mg/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 50% Glycerol
Activated protein C cofactor
Coagulation factor V
coagulation factor V (proaccelerin, labile factor)
coagulation factor V jinjiang A2 domain
Coagulation factor V light chain
Factor V Leiden
proaccelerin, labile factor
Protein C cofactor
FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Involvement in diseaseFactor V deficiency Thrombophilia due to activated protein C resistance Budd-Chiari syndrome Ischemic stroke Pregnancy loss, recurrent, 1
Sequence similaritiesBelongs to the multicopper oxidase family. Contains 3 F5/8 type A domains. Contains 2 F5/8 type C domains. Contains 6 plastocyanin-like domains.
DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
Post-translational modificationsThrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylation sites are present in the extracellular medium.