Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesCow
    • Additional sequence informationSource = fresh bovine plasma

Specifications

Our Abpromise guarantee covers the use of ab62236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Additional notesConcentartion varies from lot to lot but is between 5-10mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol

General Info

  • Alternative names
    • Activated protein C cofactor
    • APC cofactor
    • Coagulation factor V
    • coagulation factor V (proaccelerin, labile factor)
    • coagulation factor V jinjiang A2 domain
    • Coagulation factor V light chain
    • F5
    • FA5_HUMAN
    • Factor V Leiden
    • FactorV
    • FVL
    • Labile factor
    • PCCF
    • Proaccelerin
    • proaccelerin, labile factor
    • Protein C cofactor
    • RPRGL1
    • THPH2
    see all
  • FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • Tissue specificityPlasma.
  • Involvement in diseaseFactor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • Sequence similaritiesBelongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • Post-translational
    modifications
    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Natural Cow Factor V protein (ab62236)

ab62236 has not yet been referenced specifically in any publications.

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