Native cow Folate Binding Protein/FBP (ab82272)
Key features and details
- Expression system: Native
- Purity: > 95% HPLC
- Active: Yes
Description
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Product name
Native cow Folate Binding Protein/FBP
See all Folate Binding Protein/FBP proteins and peptides -
Biological activity
Activity: 18.6ug/ml (Folate binding) -
Purity
> 95 % HPLC. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Cow -
Additional sequence information
Source = bovine milk
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Specifications
Our Abpromise guarantee covers the use of ab82272 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Form
Liquid -
Additional notes
Source: bovine milk. Protein content: 2.3mg/ml (indirectly using the measured activity in ug/ml and the binding capacity of 8ug folic acid/mg Folate binding protein.) .
Previously labelled as Folate Binding Protein
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 1.968% Sodium phosphate, 0.174% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- adult
- Adult folate binding protein
- Adult folate-binding protein
see all -
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. -
Tissue specificity
Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. -
Involvement in disease
Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. -
Sequence similarities
Belongs to the folate receptor family. -
Post-translational
modificationsEight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. -
Cellular localization
Cell membrane. Secreted. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab82272 has been referenced in 1 publication.
- Kim HS et al. Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling. Mol Biol Cell 29:523-531 (2018). PubMed: 29298840