Natural cow Folate Binding Protein (ab82272)

Overview

Description

  • NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesCow
    • Additional sequence informationSource = bovine milk

Specifications

Our Abpromise guarantee covers the use of ab82272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivity: 18.6ug/ml (Folate binding)
  • FormLiquid
  • Additional notes

    Source: bovine milk. Protein content: 2.3mg/ml (indirectly using the measured activity in ug/ml and the binding capacity of 8ug folic acid/mg Folate binding protein.) .

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30mM Sodium chloride, 120mM Sodium phosphate, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • adult
    • Adult folate binding protein
    • Adult folate-binding protein
    • FBP
    • Folate receptor
    • Folate receptor 1
    • Folate Receptor 1 Adult
    • Folate Receptor 1 Precursor
    • Folate receptor adult
    • Folate receptor alpha
    • FOLR
    • FOLR1
    • FOLR1_HUMAN
    • FR alpha
    • FR-alpha
    • FRalpha
    • KB cells FBP
    • MOV18
    • Ovarian cancer associated antigen
    • Ovarian tumor associated antigen
    • Ovarian tumor associated antigen MOv18
    • Ovarian tumor-associated antigen MOv18
    see all
  • FunctionBinds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • Tissue specificityExclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
  • Involvement in diseaseDefects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
  • Sequence similaritiesBelongs to the folate receptor family.
  • Post-translational
    modifications
    Eight disulfide bonds are present.
    The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
  • Cellular localizationCell membrane. Secreted.
  • Information by UniProt

References for Natural cow Folate Binding Protein (ab82272)

ab82272 has not yet been referenced specifically in any publications.

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The protein concentration of this product is not measured directly. The protein concentration is calculated from the folate binding activity (ug folic acid...

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