Native Human Apolipoprotein CII/ApoC-II (ab90925)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
Description
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Product name
Native Human Apolipoprotein CII/ApoC-II
See all Apolipoprotein CII/ApoC-II proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab90925 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Additional notes
Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.This product was previously labelled as Apolipoprotein CII
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20ºC.
pH: 7.40
Constituent: 0.079% Ammonium bicarbonate -
ReconstitutionAfter initial centrifugation, we suggest the addition of the lyophilization buffer (10 mM ammonium bicarbonate, pH 7.4) to the original volume, followed by gentle swirling and/or vortexing to ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
General Info
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Alternative names
- APC 2
- APC2
- Apo CII
see all -
Function
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. -
Tissue specificity
Liver and intestine. -
Involvement in disease
Hyperlipoproteinemia 1B -
Sequence similarities
Belongs to the apolipoprotein C2 family. -
Post-translational
modificationsProapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE analysis of ab90925 on an 18% Tris-Glycine Gel
Lane 1: Apolipoprotein CII/ApoC-II - 10 μg (Reduced/heated)
Lane 2: Apolipoprotein CII/ApoC-II - 15 μg (Reduced/heated)
Lane 3: Molecular weight markers
Lane 4: Apolipoprotein CII/ApoC-II - 10 μg (Non-reduced/no heat)
Lane 5: Apolipoprotein CII/ApoC-II - 20 μg (Non-reduced/no heat)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab90925 has not yet been referenced specifically in any publications.