Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab62258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    Purified using a combination of ion exchange and affinity chromatography.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: Glycine buffered saline

  • Reconstitution
    Reconstitution by adding 1 ml of water for a final concentration of 0.1 mg/ml.

General Info

  • Alternative names
    • Activated protein C binding protein
    • Activated protein C-binding protein
    • Anticardiolipin cofactor
    • APC inhibitor
    • Apo-H
    • APOH
    • APOH_HUMAN
    • Apolipoprotein H
    • apolipoprotein H (beta-2-glycoprotein I)
    • B2G1
    • B2GP1
    • B2GPI
    • Beta 2 glycoprotein I
    • Beta 2 glycoprotein I precursor
    • Beta(2)GPI
    • Beta-2-glycoprotein 1
    • Beta-2-glycoprotein I
    • BG
    • Glycoprotein 1, beta-2
    • Glycoprotein I, beta-2
    • OTTMUSP00000003033
    see all
  • Function
    Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
  • Tissue specificity
    Expressed by the liver and secreted in plasma.
  • Sequence similarities
    Contains 4 Sushi (CCP/SCR) domains.
  • Post-translational
    modifications
    N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

This product has been referenced in:
  • Brochado MJ  et al. Correlation between beta-2-glycoprotein I gene polymorphism and anti-beta-2 glycoprotein I antibodies in patients with multibacillary leprosy. Arch Dermatol Res 302:583-91 (2010). ELISA . Read more (PubMed: 20140737) »

See 1 Publication for this product

Customer reviews and Q&As

1. This product is not tested for endotoxin nor do we claim that this product is endotoxin free.
2. We do not include azide in the formulation for this product.

Thank you for your enquiry and your interest in our product.
I can confirm that these two products (ab62258 and ab115215) have not been tested together. Whilst ab62258 has been characterized for ELISA and SDS-PAGE; ab115215 has been tested in IHC-...

Read More

Thank you for your enquiry. ab62258 is full length native Human Apolipoprotein H isolated from fresh frozen plasma. We have not tested the protein activity, its presence/purity has been tested in an ELISA and SDS-PAGE. We do not stock Apolipoprotei...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up