This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activation peptide fragment 1
Activation peptide fragment 2
Coagulation factor II
coagulation factor II (thrombin)
prothrombin B chain
Thrombin heavy chain
Thrombin light chain
RelevanceThrombin is an active enzyme in the earliest steps of the blood clot formation, generated from its circulating inactive precursor prothrombin. Thrombin is a glycoprotein formed by two peptides chains of 36 and 259 amino acids linked by disulfure bonds. Three important sites have been identified on the surface of the enzyme: The catalytic site that confers to the molecule its serine protease activity, the exosite one responsible for the binding of the substrate (fibrinogen or thrombin receptor) and the exosite two responsible for the binding of antithrombin III and inactivation of thrombin.
Beta Thrombin is a proteolyzed form of Alpha Thrombin.