The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesStarting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.
Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0µ mole of Butyrylcholine per min at pH 8.0 at 37°C.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C.
Constituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionUse of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.
Choline esterase II
Cholinesterase (serum) 2
FunctionEsterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Tissue specificityDetected in blood plasma (at protein level). Present in most cells except erythrocytes.
Involvement in diseaseDefects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.