Natural human Butyrylcholinesterase protein (ab96367)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      65 kDa
    • Amino acids
      29 to 602

Specifications

Our Abpromise guarantee covers the use of ab96367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    >100 U/mg.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Lyophilised
  • Additional notes
    Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies. Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0µ mole of Butyrylcholine per min at pH 8.0 at 37°C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C.

    Preservative: None
    Constituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Use of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.

General Info

  • Alternative names
    • Acylcholine acylhydrolase
    • BCHE
    • Butyrylcholine esterase
    • CHE1
    • CHE2
    • CHLE_HUMAN
    • Choline esterase II
    • Cholinesterase
    • Cholinesterase (serum) 2
    • Cholinesterase 1
    • E1
    • Pseudocholinesterase
    • Pseudocholinesterase E1
    see all
  • Function
    Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
  • Tissue specificity
    Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
  • Involvement in disease
    Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
  • Sequence similarities
    Belongs to the type-B carboxylesterase/lipase family.
  • Cellular localization
    Secreted.
  • Information by UniProt

References for Natural human Butyrylcholinesterase protein (ab96367)

ab96367 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab96367.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up