Natural human Cathepsin G protein (ab91122)

Overview

Description

  • Nature
    Native
  • Source
    Native
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab91122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: 2-4 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one µmole of Suc-Ala-Ala Pro-Phe-pNA (1 mM) per minute at 25°C in 160 mM Tris-HCl, pH 7.4, with 1.6 M NaCl.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Additional notes
    Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 0.66. Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti- HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Preservative: None
    Constituents: dH2O (Salt-free)

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CATG
    • CATG_HUMAN
    • Cathepsin G
    • Cathepsin G precursor
    • CathepsinG
    • CG
    • Ctsg
    • CTSG protein
    • MGC23078
    see all
  • Function
    Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
  • Cellular localization
    Cell surface.
  • Information by UniProt

Images

  • SDS-PAGE: 12% Tris-HCl gel
    Lane 1. 5 µg Cathepsin G (reduced/heated)
    Lane 2. 10 µg Cathepsin G (reduced/heated)
    Lane 3. 20 µg Cathepsin G (reduced/heated)
    Lane 4. Molecular weight markers
    Lane 5. 5 µg Cathepsin G (non-reduced/no heat)
    Lane 6. 10 µg Cathepsin G (non-reduced/no heat)
    Lane 7. 20 µg Cathepsin G (non-reduced/no heat)

References

ab91122 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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