• NatureNatural
  • SourceNative
  • Amino Acid Sequence
    • SpeciesHuman


Our Abpromise guarantee covers the use of ab7538 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot



    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

  • FormLiquid
  • Additional notes


    This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type VI. Reaction with anti-Collagen I, II, III, IV or V is negligible (typically less than 1% cross reactivity was detected by ELISA).


    This product is stable at 4° C as an undiluted liquid.

    Dilute only prior to immediate use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C. Store undiluted.

    Preservative: 0.01% Sodium azide
    Constituent: 0.6% Acetic acid

General Info

  • Alternative names
    • Alpha 1 (VI) chain (61 AA)
    • CO6A1_HUMAN
    • COL6A1
    • COL6A2
    • COL6A3
    • Collagen alpha 2(VI) chain
    • Collagen alpha 3(VI) chain
    • Collagen alpha-1(VI) chain
    • Collagen type VI alpha 1
    • Collagen type VI alpha 2
    • Collagen type VI alpha 3
    • Collagen VI alpha 1 polypeptide
    • Collagen VI alpha 2 polypeptide
    • Collagen VI alpha 3 polypeptide
    • CollagenVI
    • Human mRNA for collagen VI alpha 2 C terminal globular domain
    • OPLL
    • PP3610
    see all
  • FunctionCollagen VI acts as a cell-binding protein.
  • Involvement in diseaseDefects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • Sequence similaritiesBelongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • Post-translational
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt

References for Natural Human Collagen VI protein (ab7538)

This product has been referenced in:
  • Veidal SS  et al. MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis - Identification and Validation of a Novel Biochemical Marker Assay. PLoS One 6:e24753 (2011). Read more (PubMed: 21935455) »

See 1 Publication for this product

Product Wall

I have contacted the laboratories who confirmed that the collagen is not assessed specifically for telopeptides. Lower molecular weight subunit strands are not expected in the unreduced collagen.

When the collagen has been loaded on 4-20% g...

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I can confirm the collagen is present as triple helices. The size is not determined but the native protein is normally too large to run in standard 4-8% polyacrylamide gels.

Thank you for keeping me updated about the results, and also for your patience while I've been in touch with the lab that produces this protein.

I do have a couple of suggestions that will hopefuly improve the results, but I was unfortunately...

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Thank you for contacting us with your question.

The collagen VI protein Ab7538 is a native protein, and it is purified full length protein isolated from human placenta. Thus it will contain the three subunits A1, A2, and A3.

I hope ...

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Thank you for contacting Abcam regarding our Collagen VI proteins.

I have confirmed with the laboratory that both proteins on our catalog have been pepsin-treated.

I hope this information is helpful and I apologize for a...

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Thanks for your call yesterday and for your patience while I have been in touch with the lab regarding your enquiry.

This protein has been treated by limited pepsin digestion.Bands most often appear between 80-120 kDa and vary depending on sa...

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I'm afraid I was unable to find out if this collagen was pepsinised. However, we do not recommend to use reduced conditions of SDS-PAGE for collagens and I would suggest to run a native (non-denaturing, non-dissociating) PAGE which should give you the ...

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